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Clinical significance of sonographic soft markers: A review
J Genet Med 2018;15:1-7
Published online June 30, 2018;  https://doi.org/10.5734/JGM.2018.15.1.1
© 2018 Korean Society of Medical Genetics and Genomics.

Mi Sun Kim, Sukho Kang, and Hee Young Cho*

Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea
Hee Young Cho, M.D. http://orcid.org/0000-0001-7064-5056
Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University School of Medicine, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Korea.
Tel: +82-31-780-5985, Fax: +82-31-780-5069, E-mail: hycho.md@gmail.com
Received December 22, 2017; Revised March 16, 2018; Accepted March 22, 2018.
cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Sonographic findings with little or no pathological significance, known as soft markers, are often found in aneuploidy fetuses. After normal screening for the aneuploidy in first trimester, there are no uniform recommendations regarding when to disregard or put on clinical significance in isolated soft markers. Associations between some soft markers and adverse pregnancy outcomes including intrauterine fetal death, preterm birth, fetal growth restriction, and congenital infection have been reported in euploidy fetuses. The present article aims to review recent literatures about the clinical significance of soft markers after normal first trimester combined screening or noninvasive prenatal testing, and propose a simple clinical summary for management of specific soft markers in pregnancies.
Keywords : Aneuploidy, Ultrasonography.


June 2018, 15 (1)
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