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Korean physicians’ attitudes toward the prenatal screening for fetal aneuploidy and implementation of non-invasive prenatal testing with cell-free fetal DNA
J Genet Med 2018;15:72-78
Published online December 31, 2018;  https://doi.org/10.5734/JGM.2018.15.2.72
© 2018 Korean Society of Medical Genetics and Genomics.

Soo Hyun Kim1, Kun Woo Kim2, You Jung Han3, Seung Mi Lee4, Mi-Young Lee5, Jae-Yoon Shim5, Geum Joon Cho6, Joon Ho Lee7, Soo-young Oh8, Han-Sung Kwon9, Dong Hyun Cha1,*, and Hyun Mee Ryu3,*

1Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea
2Department of Obstetrics and Gynecology, Hamchoon Women’s Clinic, Seoul, Korea
3Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea
4Department of Obstetrics and Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea
5Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
6Department of Obstetrics and Gynecology, Korea University Guro Hospital, Seoul, Korea
7Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University Health System, Seoul, Korea
8Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
9Department of Obstetrics and Gynecology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
Dong Hyun Cha M.D., Ph.D. http://orcid.org/0000-0003-0722-1714
Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University School of Medicine, 566 Nonhyun-ro, Gangnam-gu, Seoul 06135, Korea.
Tel: +82-2-3468-3314, Fax: +82-2-558-1112, E-mail: chadh001@chamc.co.kr
Hyun Mee Ryu, M.D., Ph.D. http://orcid.org/0000-0002-0710-2582
Department of Obstetrics and Gynecology, Cheil General Hospital and Women’s Healthcare Center, Dankook University College of Medicine, 17 Seoae-ro 1-gil, Jung-gu, Seoul 04619, Korea.
Tel: +82-2-2000-7175, Fax: +82-2-2000-7793, E-mail: hmryu2012@naver.com
Received November 2, 2018; Revised December 13, 2018; Accepted December 13, 2018.
cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Purpose: Physicians' attitudes may have a strong influence on women’s decision regarding prenatal screening options. The aim of this study is to assess the physicians’ attitudes toward prenatal screening for fetal aneuploidy including non-invasive prenatal testing (NIPT) in South Korea.
Materials and Methods: Questionnaires were distributed and collected at several obstetrics-gynecological conferences and meetings. The questionnaire included 31 multiple choice and 5 fill-in-the-blank questions. Seven questions requested physicians’ demographic information, 17 questions requested information about the NIPT with cell-free fetal DNA, and 12 questions requested information about general prenatal screening practices.
Results: Of the 203 obstetricians that completed the survey. In contrast with professional guidelines recommending the universal offering of aneuploidy screening, only 53.7% answered that prenatal aneuploidy testing (screening and/or invasive diagnostic testing) should be offered to all pregnant women. Physicians tended to have positive attitudes toward the clinical application of NIPT as both primary and secondary screening methods for patients at high-risk for fetal trisomy. However, for patients at average-risk for fetal trisomy, physicians tended to have positive attitudes only as a secondary screening method. Physicians with more knowledge about NIPT were found to tend to inform their patients that the detection rate of NIPT is higher.
Conclusion: This is the first study to investigate expert opinion on prenatal screening in South Korea. Education of physicians is essential to ensure responsible patient counseling, informed consent, and appropriate management after NIPT.
Keywords : Physicians' practice patterns, Prenatal diagnosis, Genetic testing, Prenatal care


December 2018, 15 (2)
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