Fig. 1. Synthesis of M6P determinants on the acidic hydrolases in the trans-Golgi network. GlcNAc-1-phosphotransferase transfer GlcNAc-phosphate moiety from UDP-GlcNAc to the oligosaccharides of acidic hydrolases. NAGPA uncovers M6P on the oligosaccharides by cleaving off terminal GlcNAc. UDP-GlcNAc, uridine diphosphate N-acetylglucosamine; UMP, uridine monophosphate; NAGPA, N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; M6P, mannose 6-phosphate.
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