Journal of Genetic Medicine : eISSN 2383-8442 / pISSN 1226-1769

Fig. 1.

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Fig. 1. The growth curve of three patients with mucopolysaccharidosis (MPS) I (A) and four patients with MPS II on disease-specific growth chart (B). (A) This is the growth curve of three patients with MPS I, excluding one who terminated the hGH treatment early because of ineffectiveness. In patient 1 (black), who was diagnosed with Hurler-Sheie syndrome, height SDS showed an increase every year after starting the hGH treatment. Patient 2 (red) was diagnosed with GHD. In patient 4 (blue), who had mild type MPS I, height SDS tended to decrease every year before starting hGH treatment. However, after starting the hGH treatment, the annual height SDS of the patient increased relatively continuously.(B) This is the growth curve of four patients with MPS II, excluding one who terminated the hGH treatment early because of ineffectiveness. In this MPS II disease-specific growth curve, height SDS shows a relatively sustained increase in four MPS II patients after starting growth hormone treatment. The height SDS at the end of treatment increased in all four patients compared to the height SDS at the start of treatment. Patient 3 (red) was diagnosed with GHD. H/S, Hurler/Scheie syndrome; hGH, human growth hormone; SDS, standard deviation score; GHD, growth hormone deficiency.
Journal of Genetic Medicine 2023;20:60-9 https://doi.org/10.5734/JGM.2023.20.2.60
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