Fig. 4. Schematic representation of neurofibromin isoform 1 and 2. A diagram showing that alternative splicing of the NF1 exon 23a can give rise to two isoforms of neurofibromin. Exon 23a, previously mentioned, is now referred to as exon 31 in the current nomenclature. CSRD, cysteine-and serine-rich domain; TBD, tubulin-binding domain; GAP, GTPase-activating protein; GRD, GAP-related domain; Sec, Sec14 homologous domain; PH, pleckstrin homologous domain; CTD, C-terminal domain; NLS, nuclear localization signal.
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